Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Identifieur interne : 000613 ( Main/Exploration ); précédent : 000612; suivant : 000614Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Auteurs : Jun Wang [États-Unis] ; Fang Li ; Chunlong MaSource :
- Peptide Science [ 0006-3525 ] ; 2015-07.
Abstract
Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.
Url:
DOI: 10.1002/bip.22623
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001721
- to stream Istex, to step Curation: 001721
- to stream Istex, to step Checkpoint: 000014
- to stream Main, to step Merge: 000614
- to stream Main, to step Curation: 000613
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
</author>
<author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name>
</author>
<author><name sortKey="Ma, Chunlong" sort="Ma, Chunlong" uniqKey="Ma C" first="Chunlong" last="Ma">Chunlong Ma</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C31C6FE1008D98D0FE36A1F885D8BE6FCE892834</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1002/bip.22623</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001721</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001721</idno>
<idno type="wicri:Area/Istex/Curation">001721</idno>
<idno type="wicri:Area/Istex/Checkpoint">000014</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000014</idno>
<idno type="wicri:doubleKey">0006-3525:2015:Wang J:recent:progress:in</idno>
<idno type="wicri:Area/Main/Merge">000614</idno>
<idno type="wicri:Area/Main/Curation">000613</idno>
<idno type="wicri:Area/Main/Exploration">000613</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson</wicri:cityArea>
</affiliation>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name>
<affiliation><wicri:noCountry code="subField">Tucson</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ma, Chunlong" sort="Ma, Chunlong" uniqKey="Ma C" first="Chunlong" last="Ma">Chunlong Ma</name>
<affiliation><wicri:noCountry code="subField">Tucson</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Peptide Science</title>
<title level="j" type="sub">Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title>
<title level="j" type="alt">PEPTIDE SCIENCE</title>
<idno type="ISSN">0006-3525</idno>
<idno type="eISSN">1097-0282</idno>
<imprint><biblScope unit="vol">104</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="291">291</biblScope>
<biblScope unit="page" to="309">309</biblScope>
<biblScope unit="page-count">19</biblScope>
<date type="published" when="2015-07">2015-07</date>
</imprint>
<idno type="ISSN">0006-3525</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-3525</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
</region>
</list>
<tree><noCountry><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name>
<name sortKey="Ma, Chunlong" sort="Ma, Chunlong" uniqKey="Ma C" first="Chunlong" last="Ma">Chunlong Ma</name>
</noCountry>
<country name="États-Unis"><region name="Arizona"><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
</region>
<name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000613 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000613 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:C31C6FE1008D98D0FE36A1F885D8BE6FCE892834 |texte= Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses }}
This area was generated with Dilib version V0.6.33. |